Multiple ministries are monitoring the situation after a first case of H5 bird flu was detected in a sea lion on a beach in Montevideo, where the River Plate empties into the Atlantic.
The dead animals have turned up on the Atlantic coast and along the river. So far 350 have been buried to stop the spread of the virus.
"This is an evolving situation now and we attribute it to bird flu," said the head of the fauna department at the environment ministry, Carmen Leizagoyen.
"The disease cannot be controlled. We have to wait for the immunity of the animals to act, but we do not know when this is going to happen," she told AFP.
Uruguay has an estimated 315,000 seals and sea lions.
Leizagoyen urged beachgoers to stay away from such animals to avoid catching the virus. Human infections with bird flu are rare but do occur.
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