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EPIDEMICS
HIV drugs reach 8 million in needy countries
by Staff Writers
Washington (AFP) July 18, 2012

Facts about HIV/AIDS worldwide in 2011
Washington (AFP) July 18, 2012 - Here are some key facts and figures on HIV/AIDS in 2011, released by UNAIDS on Wednesday ahead of the International AIDS Conference set to take place in Washington on July 22-27.

HIV WORLDWIDE

34.2 million people were living with HIV in 2011, more than ever before due to the life-extending benefits of antiretroviral medication.

AIDS DEATHS

1.5 million people died of AIDS last year. The leading cause of death was tuberculosis.

DEATH TRENDS in 2011

SUB-SAHARAN AFRICA: 1.2 million people died of AIDS-related causes, down from a peak of 1.8 million in 2005.

ASIA: An estimated 330,000 people died of AIDS-related causes, the largest number of deaths outside sub-Saharan Africa. Death trends are relatively stable.

EASTERN EUROPE, CENTRAL ASIA: An estimated 90,000 people died of AIDS-related causes, six times higher than a decade earlier in 2001, when 15,000 died.

MIDDLE EAST, NORTH AFRICA: AIDS-related deaths rose to 25,000 last year, up from 14,000 a decade earlier.

LATIN AMERICA: Some 57,000 people died of AIDS-related causes, down from 63,000 a year earlier.

WESTERN AND CENTRAL EUROPE, NORTH AMERICA: An estimated 29,000 people died of AIDS-related causes.

NEW INFECTIONS

An estimated 2.5 million people worldwide were newly infected with HIV in 2011, down 20 percent from a decade earlier. Among children, there were 330,000 new infections last year, down 24 percent from 2009.

TRENDS IN NEW INFECTIONS

About 1.5 million adults were newly infected with HIV in sub-Saharan Africa in 2011, fewer than in any year since 1997, when the epidemic reached its height with 2.2 million new infections.

ARV TREATMENT

In 2011, more than eight million people were taking antiretroviral drugs in low- and middle-income countries, or about 54 percent of the 14.8 million people whose immune systems were weakened to the point of needing therapy.

MONEY

Global investments for HIV totaled $16.8 billion in 2011.

US HIV BAN

The last world AIDS conference to take place in the United States was in 1990 in San Francisco. A US ban on travel to the country by people with HIV kept the conference away. The ban was lifted by the US government in 2008 and 2009. But there are still 46 countries or territories that restrict entry for people with HIV.



More than eight million people -- a record number in low- and middle-income countries -- are now taking antiretroviral drugs to treat HIV, according to data released Wednesday by UNAIDS.

The rise in drug coverage in 2011 was accompanied by a dramatic 31 percent drop in deaths from AIDS-related causes in sub-Saharan Africa, the area of the world most ravaged by the disease, compared to the peak of the epidemic in 2005.

In all low- and middle-income countries, the availability of antiretroviral drugs grew by more than 20 percent in just one year, over the latest figure of 6.6 million people covered in 2010, said the report.

Now, more than half (54 percent) of the estimated 14.8 million people in need of antiretrovirals in those countries can access them, according to the figures released in Washington ahead of the International AIDS Conference next week.

The report said the advance "puts the international community on track to reach the goal of 15 million people with HIV receiving treatment by 2015," an aim unanimously agreed by UN member states.

"But access (to treatment) is not universal. We still have a problem with access in Asia, in Eastern Europe, Central Asia so we need to redouble the effort," said UNAIDS Executive Director Michel Sidibe.

Those parts of the world are seeing deaths and new infections rise "in a very alarming way," he said.

More governments have stepped up funding to help those suffering within their own borders, with 81 countries increasing their domestic investments for AIDS by more than 50 percent between 2006 and 2011.

Overall, low- and middle- income countries invested $8.6 billion in responding to HIV/AIDS last year, an increase of 11 percent over 2010. International funding remained flat at 2008 levels of $8.2 billion.

Total worldwide investment in HIV totaled $16.8 billion last year, an 11 percent rise from 2010, but still far short of the $22-24 billion needed by 2015, the report said.

Nearly half (48 percent) of all international assistance for HIV response last year came from the United States, which is hosting the July 22-27 scientific meeting expected to draw 25,000 people.

US AIDS Coordinator Eric Goosby said reducing the impact of AIDS worldwide was a "priority" for the US government and called for nations to step up their involvement in local AIDS programs.

"If we do not aggressively move to work with our colleagues in country to expand their capacity to manage, oversee, monitor and evaluate these programs, regardless of resources we will fail," he said.

Reacting to the UNAIDS report, Doctors Without Borders also made a plea for faster pace in treatment and a boost in worldwide funding.

"Globally, we're finally past the half-way mark with HIV treatment, but that still means almost one in two people don't have access to the medicines they need to stay alive," said a statement by Eric Goemaere, the group's senior HIV/TB adviser in southern Africa.

"If we're going to reach all people who need treatment, we have to double the pace of scale-up and double the funds."

Other highlights of the UNAIDS report included the drop in the costs of antiretrovirals, from $10,000 per person in 2000 to less than $100 per person in 2011 for the least expensive WHO-recommended regimen.

Fewer children were infected with HIV in 2011 -- about 330,000 worldwide -- down 24 percent from 2009.

But a staggering 3.4 million children under 15 were living with HIV last year, 91 percent of them in sub-Saharan Africa.

The statistics were alarming for young women, too, with HIV named as the leading cause of death in women of reproductive age globally and those aged 15-24 facing infection rates that are double those of males the same age.

An estimated 1.2 million women and girls were newly infected with HIV last year, according to the report.

It also hailed studies showing that treatment with antiretrovirals could reduce the risk of transmission from an infected person to a healthy partner by 96 percent.

The report described a "significant reduction" in transmission to uninfected people who are at high risk through sexual activity and who take the drugs as a preventive measure, though it noted a "major challenge" in adhering to daily therapy.

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HIV drug resistance creeps higher: WHO
Washington (AFP) July 18, 2012 - Drug resistance to HIV medicines has been creeping higher in parts of Africa and Asia but is not steep enough to cause alarm, said a survey released by the World Health Organization on Wednesday.

In low- and middle-income countries, drug resistance stood at 6.8 percent in 2010, the WHO said in its first-ever report on the matter released ahead of the International AIDS Conference in the US capital July 22-27.

"That is a level that we sort of expected. It is not dramatic but we clearly need to look very carefully on how this would evolve further," WHO AIDS chief Gottfried Hirnschall said in an interview.

Drug resistance can occur when the virus mutates naturally, when treatment is interrupted or patients take the medications incorrectly.

The 6.8 percent figure relates to the level of HIV drug resistance transmitted from one person to another, meaning those people were found to be resistant to the first-line of therapy they tried.

The other main type of resistance is one that develops in a patient who takes medications irregularly.

Since many more people in the developing world are now receiving antiretroviral drugs, experts have been closely monitoring to see whether a surge in drug resistance would accompany the increased coverage.

Some eight million people in low- and middle-income countries were being treated with antiretrovirals last year, up 20 percent from 2010 according to a separate report by UNAIDS released Wednesday.

High-income countries, many of which began widescale treatment for HIV years earlier and used single or dual therapies that can also encourage resistance, face higher rates of resistance, from eight to 14 percent, said the study.

However, those rates have largely leveled off or decreased over time, Hirnschall noted.

"What we have also seen in these countries is it has stabilized or plateaued while we are still seeing a slight increase in low- and middle-income countries," he told AFP.

In 12 of the low- and middle-income countries included in the study, health care facilities lost contact with up to 38 percent of people who began treatment.

When people interrupt or stop their treatment altogether, "this not only means that they are themselves more likely to become sick, it also increases the likelihood that drug resistance will emerge and the resistant virus could be transmitted to others," the report said.

The WHO called for every clinic providing such treatment to monitor for early warning indicators that could signal encroaching resistance, including poor adherence to treatment, types of medicines used and supply breaks.

Also, any rise in the amount of virus detected in the patient's blood should serve as a signal that the treatment is failing, the WHO said.

For now, there is no need to change to current guidelines for administering antiretroviral drugs due to the slight rise in resistance, it added.

"Simpler regimens using fixed-dose combinations have made it much easier for people to adhere to antiretroviral treatment, limiting the spread of drug resistance in recent years. This is good news for public health," Hirnschall said.



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EPIDEMICS
UNAIDS welcomes US approval of drug to stop HIV
Geneva (AFP) July 17, 2012
The UN agency tasked with fighting AIDS on Tuesday welcomed the decision by the United States to allow the use of an HIV prevention pill for the first time. The pill will be used "to prevent the sexual transmission of HIV for people who do not have HIV, but who are at high risk of being exposed to the virus", UNAIDS said in a statement from its Geneva headquarters. Since 2004, the combin ... read more


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