Washington accuses Maduro of heading a drug cartel and has deployed significant military assets -- including stealth warplanes and seven US Navy ships -- as part of what it says are counter-narcotics efforts in the region.
Maduro, an authoritarian socialist who is widely accused of stealing elections last year, claims Washington is plotting regime change.
Asked at the White House about reports that Caracas had floated de-escalation plans, Trump was scathing.
"He has offered everything, you're right. You know why? Because he doesn't want to fuck around with the United States," he said.
Venezuela's vice president, Delcy Rodriguez, on Thursday denied a Miami Herald report that she had negotiated with Washington on a plan to oust Maduro.
Venezuela is the alleged origin of some of the vessels, at least six of which have been targeted and mostly involving speedboats, in an unprecedented campaign of US strikes in the Caribbean since September.
The latest attack left survivors on board, media outlets including CBS and NBC reported, citing unidentified US officials.
US media later reported Friday the two survivors were in the custody of the US Navy, with no further details available on their conditions or circumstances.
Trump said the target was a "drug-carrying submarine built specifically for the transportation of massive amounts of drugs."
Semi-submersibles built in clandestine jungle shipyards have for years been used to ferry cocaine from South America, particularly Colombia, to Central America or Mexico, usually via the Pacific Ocean.
Washington says its Caribbean campaign is dealing a decisive blow to drug trafficking, but it has provided no evidence that the people killed -- at least 27 so far -- were drug smugglers.
Experts say such summary killings are illegal even if they target confirmed narcotics traffickers.
The US campaign has drawn in some of Venezuela's neighbors.
Police in Trinidad and Tobago, located off the coast of Venezuela, is investigating whether two of its citizens were killed in a strike on Wednesday.
And Colombian President Gustavo Petro says he believes Colombians have also died in the attacks.
A defiant Trump this week announced plans to ramp up operations against Venezuela, fuelling speculation that his administration aims to topple Maduro.
Trump indicated he had authorized covert CIA operations against Venezuela and was considering strikes on land targets.
Earlier this week, in a show of force, US-based B-52 bombers circled over the Caribbean off Venezuela's coast for several hours, data from tracking website Flightradar24 showed.
Venezuela has deployed 17,000 troops to Tachira state, which borders Colombia, in response to the US threats.
Venezuelan forces are also stationed in southern Amazonas state, which borders both Colombia and Brazil, and multiple coastal areas.
While Trump weighs whether to expand US military action from the sea onto land, the admiral overseeing the naval strikes in the Caribbean announced he will step down.
The head of US Southern Command gave no reason for retiring just a year into his tenure, which follows multiple top US military officers being dismissed in recent months.
Venezuela says defenses against US deployment now ready
Caracas (AFP) Oct 18, 2025 -
With US warships deployed off Venezuela's coast, President Nicolas Maduro said Saturday a plan to defend against what he called American threats is now complete.
Washington accuses Maduro of heading a drug cartel and has deployed significant military assets -- including stealth warplanes and several US Navy ships -- as part of what it says are counter-narcotics efforts in the Caribbean.
Maduro, an authoritarian socialist who is widely accused of stealing elections last year, says Washington is plotting regime change.
Trump has indicated that he authorized covert CIA operations against Venezuela, without offering specifics.
Maduro has responded to the big US military operation by ordering exercises around the country and positions soldiers at the borders.
"Today we have completed all the country's integrated defense zones," Maduro said in a recording released on Telegram.
He also announced a new military exercise he called Independence 200.
Many such exercises are carried out at night and do not conclude with new, permanent positioning of military forces.
State TV aired footage of soldiers leaving barracks.
Police, civil protection staff and civilian militia members have also taken part in Venezuela's exercises amid tensions with the United States.
US forces in the Caribbean have now attacked at least six vessels that Washington said were taking drugs from the Venezuela toward the United States, killing at least 27 people.
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